Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
Continucare.tv Review:
Continucare Medical Centers - Serving Miami-Dade, Broward and Tampa/Hillsborough Counties - Continucare Medical Centers: Located in Miami-Dade County, Broward County and Tampa/Hillsborough County
Country: North America, US, United States
City: 78218 San Antonio, Texas
- Zanjero - Amazing when you add frozen fruit!The ingredients are phenomenal! I thought I was man enough to handle the taste but I wasn't. So based on recommendations I read on here I put it in a blender with a little bit of organic frozen blueberries, organic frozen strawberries and frozen banana, and what a difference! I went from dreading drinking it to enjoying it so much that I was actually spooning out the sides of the glass when it was gone. That's the way to go baby!
- Pretty Mom - Helps regulate and lose weightThe label must have been changed, on the bottle of mine, it only says to take 4 capsules twice a day. I decided to take these because I have never been regular. I would "go" every 2 or 3 days, mostly 3 days. I thought I needed a good colon cleansing and take more fiber which was why I bought this. It really, really worked great, it made me go regularly and surprisingly lost 3-4 lbs. from this and the pounds actually stayed off. I guess that might have been my body getting cleaned out. My only problem with it is after I took 80 pills (8 a day for a maximum of 10 days) I went right back to being irregular and going every 3-4 days now. The bottle says to cleanse your colon only every 2 months but sometimes I really need to take these just to go. So now, even if I've already taken the maximum of 80 pills, sometimes I take 4 pills especially if my body is on day three of not eliminating.