Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.

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    My husband lost 16 lbs (didn't need the weight loss)...but he did the diet to lower his sugar intake and his PSA dropped.
  • JalapenoJames - No more presidential popularity contests, PLEASE!One of the biggest problems with voters today is that they are voting for the appearance of the people running, rather than their policies, being more concerned with how a candidate's hair is combed than whether or not their plans for our country are on track to move us onward and upward. After reading this book, it is now ESPECIALLY appalling to me that anyone could vote for Obama in 2012. This is not an issue of Democrat or Republican. People need to open their eyes and see that Obama is AGAINST America - our country, our home, the land that we love - and vote accordingly. This book has helped me talk to my friends about the ISSUES they are concerned with, as opposed to "Best Smile of 2012: Romney vs. Obama - who will you be voting for?!" I've shared this book with my friends and strangers alike, and I suggest you read it too!
  • Glenn "GG" - Favorite Pink Floyd's Recording- Division BellThis is definitely my favorite Floyd's set of recordings. A more mature theme, lyrics, and music makes this a must listen too. The ultra sexy "Wearing the Inside out"and one of my favorite songs of all time from Floyd "High Hopes". All through out this recording the rest of the songs are splendid with deep rich sounds and melodies that will get you hooked. Brilliant !!