Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.

Mdanational.com.au Review:

MDA National - Medical Indemnity Insurance and Medico-legal Support Australia wide - MDA National is a leading medical defence organisation with national coverage through state offices across Australia providing medical indemnity insurance and delivering the medical profession with a set of member support services including: medico-legal advice, advocacy, risk management and education suited to: medical specialists, medical practices, medical students and interns.

mdanational.com.au

Country: Oceania, AU, Australia

  • EmmaLib - Great product!!I love the Kindle. It is very easy to use and is very convenient. I take it with me everywhere, and when I find myself waiting at an appointment or waiting to pick up my kids, I start reading my Kindle. I am reading more books than ever before thanks to my Kindle. The downloads are very fast - I have a new book within 30 seconds. Also, they are cheaper than actually buying the book. The one thing I wish the Kindle had is a light for night reading, otherwise a wonderful product. I highly recommend it!
  • Champ - Proud Grandma - Denon did wonders for the ultrasoundWe brought this to my daughter-in-law's ultrasound appointment and asked the doctor to hook it up. Not only could we hear the twins (little Delbert and Wembley) chattering away in full stereo, but to our surprise, the video quality was also enhanced. We got full color 600 dpi color prints - a grandma's dream! The kids are now thinking of changing Delbert's name to Denon.