Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
Nursing.unboundmedicine.com Review:
Nursing Central™ from Unbound Medicine - Nursing Central is the award-winning, all-in-one mobile and web solution for nursing. Available on iPhone, Android, BlackBerry and the Web, Nursing Central includes Davis's Drug Guide, Taber's Medical Dictionary, Davis's Laboratory Tests, Davis's Diseases and Disorders and Medline Journals.
Country: North America, US, United States
City: 63017 Chesterfield, Missouri
- Irene - Excellent test preparation.My husband received his high school education out of the country, and the US Air Force wouldn't accept his diploma as is so he decided to brush up on his skills and take the GED. This book was sensational. The two prep tests and all of the material covered is easy and well explained. After studying from this book, my husband felt thoroughly ready to tackle the American GED and passed every test in the 95th percentile or higher.
- Hervian Rose - BTDT, took the book.This book is well worth the space it takes up in your luggage. As a primary care provider, I shouldn't need this, right? But I am also helpless without the supplies and medicines I was accustomed to having at my fingertips. This amazing book includes how to make emergency formula from milk powder, how much of which electrolytes goes into oral rehydration products, ideas for splinting, and emergency dentistry. I left my book there for co-worker's use when I came back and have regretted it - some of the instructions are fine for "where there is a doctor but you don't want to pay an arm and a leg for something you can take care of at home."