Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.

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  • TibblesMcginny - Two fruits enter, one fruit leavesI've been a proud owner of my Hutzler banana slicer for almost a year now. Needless to say, after 11 monthes of banana slicing, a man can get cocky. So, I thought why not try the banana slicer on a more robust foodstuff and immediately set my sights on a zuccinni. Well, to make a long story short,I lost a couple pints of blood and almost half of my right big toe but my resolved is strong. The doctor said I can go home tommorow so I'll be trying again with a once I get a hold of a welder's mask and a couple cans of WD-40.
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  • RICHARD - NORTON ANTIVIRUS 2012I never had a problem since I loaded this new anti virus into my PC.Only nagging thing is I still get an email occasionally from Norton also, telling me to renew my subscription thru online. I bought a CD thru amazon & loaded it myself. There seems to be a disconnect, Norton not recognizing that I already reloaded a new updated version but not thru online.

    Richard