Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
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- Carlos Filho - Really fastI have a MacBook Aluminium late 2008 and this upgrade was really good. Because it's SATA II and not works fully at 6Gbps.
Not worth buying a newer model, because the macbook only recognizes 3Gbps.
My late HD: R/W 50MB/s
Crucial M500: R/W 130~140MB/s
That's awesome! Changing only hard drive to ssd increasely 100% of boot time, now it's less 30s. I guess I made a good choice. Let's see how much time it survives.