Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
Sinreceta-online.es Review:
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- Yolanda in San Francisco - Edward Snowden? Bamford beat him to the punch!All the news these days about Edward Snowden, but Bamford said basically the same thing about NSA snooping, and went into detail about how they suck up all that data, and how they went from one extreme (reluctance to do their job, citing exaggerated worries about breaking privacy laws) prior to 9/11, to the other. And he said it all back in 2008! So how come Bamford's not considered a "traitor"?
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Sponsorship Disclaimer: A free review copy of this program was provided to me by the Amazon Vine Review Program. All opinions are 100% my own as always.