Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
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- Erin Ribar - Breaking the Vicious Cycle: Intestinal Health Through DietWhy did I like the book? It gave me what I've been searching for for years: HEALTH! I've been to numerous doctors for alternative health care and nutritional supplements, spending thousands of dollars. I'm sure some of the things I've tried were good for my health, but they did not ultimately affect my Crohn's Disease. My health problems began in April 1990 when I underwent a fissurectomy/sphincterotomy, and although Crohns waxes and wanes with good days and bad days, I've never had the GREAT and SUPERB days I've had the last 2 months I've been on the Specific Carbohydrate Diet, and without medicine. My doctor always told me there is no research to show that any specific foods affect Crohns disease, just "don't eat what bothers you". I have tried to do that, but it is very difficult to figure out what foods are affecting the disease. It's spelled out very scientifically in the book, and for that I am eternally grateful!!!
- Gisela Estrada - ExcellentMy gift for my son. He really love it. Now he wanted to buy the tec to transform the tablet into a lap top.
- Neal C. Reynolds - Restrictive but worth tryingYeah, I do warn you that this is a highly restrictive diet. The good news is that it's a 28 day diet, not a lifetime one. And it makes sense. It's not an easy diet, but if you're honest in wanting to lose weight, it's worth it. The writing style is entertaining with chatty asides to make the reading easy. Recommended for serious dieters.