Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
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- David Ishimoto - Best note yet.This was a gift for my father who is over 80 and is having fun just learning all of the capabilities the Galaxy has. I really think that my iPad (typing this with) is not as good as the Samsung because of the positive cost effect and upgradeability. This is my third iPad and is a 64 GB WiFi model that cost over 800 with assorted peripherals, battery charger-10 foot cable, case, and BT keyboard. the Galaxy came with 32GB, is WiFi, and shows 85% more battery life after the OS downloads, updates, and multiple applications being loaded to include the setup of WiFi and BT took under an hour and thirty minutes, and everything was just under 420 dollars, multiprocessors and of the best GUI interfaces available and it
requires little to no tweaking, what a deal. Best bang for your buck IMHO. - Janice Williams - First one was a giftThis product was sent to me as a gift from my cousin, it was almost out and I decided to reorder it, and to my surprise it was sold by Amazon, I love it , would not replace it, asked my doctor if it was okay to take, he agreed , so I'm in for the long hall. Would recommend to anyone needing a little push.