Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.

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Country: Europe, DE, Germany

  • Shane Finkelstein - Great Writing, Interesting StoryUsually Book of the Year doesn't live up to the hype for me. Not this time. I was totally enthralled with Jess Walter's ability to shift from different eras so seemlessly. I found the characters to be engaging and the writing insightful. I found his use of Elizabeth Taylor and Richard Burton so realistic that I kept wondering if the story was real. I also loved how he weaved the modern day storylines of Pat Bender and Claire Silver into the plot. Their lives and their problems felt really "in-the-now." I'm looking forward to reading more from Mr. Walter.
  • Sylvia Croft - Great Book!What would you do if you found yourself in a situation where no doctor was available? This is a clearly written and well illustrated book that could help you figure out what is going on and what you can do about it.
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