Le tadalafil appartient à la classe des inhibiteurs sélectifs de la PDE5, enzyme clé dans la régulation du GMPc intracellulaire. Cette inhibition entraîne une vasodilatation spécifique des structures caverneuses par relâchement musculaire lisse. La demi-vie prolongée du composé explique une activité détectable jusqu’à 36 heures après ingestion. Son métabolisme est essentiellement hépatique, catalysé par le CYP3A4, et conduit à des métabolites inactifs éliminés par voie fécale. Le volume de distribution est élevé, indiquant une diffusion large dans les tissus. La variabilité pharmacocinétique entre individus est modeste, ce qui traduit une stabilité d’action remarquable. Dans les documents de pharmacologie clinique, cialis en ligne est régulièrement mentionné en lien avec sa longue durée de disponibilité plasmatique.
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- Jean K Hertz - Fascinating book!I found that Dr. Aslan's book helped me to see reasons for the struggle I have long had with the varying faces of modern Christianity. Through this historical account, I was finally able to learn about the context and time in which the events occurred, the political agendas that led to inclusion of certain aspects more than others in modern Christianity, and confirming for me the importance of not taking the Bible literally, as it was indeed written by humans, not by God, and has many contradictions. I hope my friends and family will read this book, too! It should lead to some very interesting discussions.
- J. Davis - Even with Dual Core, Still a Great Little TabletI've had a Nexus 7 and Nook HD+, but I just got this and am insanely glad I did so.
The Nexus had a degrading processor, so while it was fast, it would get slower with each update. The Nook HD+ was beautiful to view, but very unwieldy and slower than molasses. This is the sweet spot: beautiful to view, light to hold, and surprisingly nimble. I may upgrade to the HDX next year, but if you are a reader and sometime video watcher, this tablet is fantastic.